1-Ethyl (3E)-2-amino-4-methyl-5-phosphono-3-pentenoate → CGP 37849

HRID 1682325Notes

Reaction equation

HRID 1682325 reaction equation
C([O:3][C:4](=[O:15])[CH:5]([NH2:14])/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])C>O>[NH2:14][CH:5](/[CH:6]=[C:7](\[CH3:13])/[CH2:8][P:9]([OH:12])([OH:11])=[O:10])[C:4]([OH:15])=[O:3]

Participants

3

Reactant 1

HCID 63723341-Ethyl (3E)-2-amino-4-methyl-5-phosphono-3-pentenoate

Product 1

HCID 5950212CGP 37849

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12 g of E-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester are stirred under reflux in 70 ml of water for 19 hours. The reaction mixture is slowly cooled to room temperature, stirred in an ice bath for one hour, filtered and washed with cold water. In this manner there is obtained E-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the form of the monohydrate, m.p. 163° (decomp.).

Workup

  1. filtrationfiltered
  2. washwashed with cold water

Sources & evidence

ORD record
ord-747a971d190c42dbb46e233aa5cb1d9d
Source dataset
uspto-grants-1992_12
Patent number
US05175344

Reaction notes

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