2-Chloropyridine → HCID 22418741, compound

HRID 1682345Notes

Reaction equation

HRID 1682345 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][NH:5][CH3:6].Cl[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1>>[CH3:1][NH:2][CH2:3][CH2:4][N:5]([CH3:6])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 8070N,N'-Dimethylethylenediamine

Product 1

HCID 22418741HCID 22418741, compound

Procedure

A mixture of N,N'-dimethylethylene-diamine (25 g) and 2-chloropyridine (1.3 g) is warmed at 85° with stirring for 18 h. The excess dimethylethylenediamine is removed by distillation at reduced pressure. The distillation residue is distributed between ethyl acetate (150 ml) and water (100 ml). The organic phase is separated, dried over sodium sulfate and the organic solvent removed under reduced pressure to give the title compound.

Workup

  1. temperatureis warmed at 85°
  2. customThe excess dimethylethylenediamine is removed by distillation at reduced pressure
  3. customThe organic phase is separated
  4. dry with materialdried over sodium sulfate
  5. customthe organic solvent removed under reduced pressure

Sources & evidence

ORD record
ord-8ce1850770724d9ca9dc75f37df47400
Source dataset
uspto-grants-1992_12
Patent number
US05175281

Reaction notes

Loading…