Dimethylformamide → HCID 14307792, compound

Participants

Reaction Steps

17α-Hydroxy-21-(1-piperazinyl)pregna-4,9(11)-diene-3,2-dione (EXAMPLE 6A, 5.00 g) is treated om DMF (20 ml) with m-chlorophenylisocyanate (1.84 g) for 3 days. The mixture is poured into water (200 ml). After 1 hr, the liquid is decanted. The solid is dissolved in methylene chloride and is extracted with aqueous sodium bicarbonate. The phases are separated and the organic phase is dried over sodium sulfate and concentrated. The concentrate is chromatographed on silica gel (3% methanol in methylene chloride to 4%) to give the title compound which is crystallized from hot ethyl acetate.

Provenance & Evidence