[2-(Pyridin-2-yl)-1,3-thiazol-4-yl]methanol → 2-(Pyridin-2-yl)-1,3-thiazole-4-carbaldehyde

HRID 1682428Notes

Reaction equation

HRID 1682428 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=1>C1(C)C=CC=CC=1.[O-2].[Mn+2]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=1

Participants

4

Reactant 1

HCID 10750266[2-(Pyridin-2-yl)-1,3-thiazol-4-yl]methanol

Product 1

HCID 21253372-(Pyridin-2-yl)-1,3-thiazole-4-carbaldehydeYield 87.1%

Reagents, catalysts & solvents 2

HCID 160959Manganese oxideCatalystHCID 1140TolueneSolvent

Procedure

5.8 g of the product of Stage D in 60 ml of toluene were refluxed for 2 hours in the presence of 13 g of manganese oxide and filtration was carried out. The solvent was evaporated under reduced pressure to obtain 5 g of the expected product melting at 131° C.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1199fb9f238f42b4b478dfad89ac424b
Source dataset
uspto-grants-1997_06
Patent number
US05635485

Reaction notes

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