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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1682492Generated: November 3, 2026

Trimethylsilyl iodide → 2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidine

https://huagongshe.com/reaction/1682492

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethylsilyl iodideHCID 85247—
Reactant2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-methoxymethylpyrimidineHCID 11739108—
SolventSulfolaneHCID 31347—
Product2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-hydroxymethylpyrimidineHCID 19705063—

Reaction Steps

This compound was made from the compound of Example 2 by reaction with trimethylsilyl iodide in sulpholane at 80° C., mp. 101°-105° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05635507
Source datasetuspto-grants-1997_06
ORD IDord-c7400d22c05f473e8c371af3120717a0
Source noteuspto-grants-1997_06