Lurosetron mesylate → HCID 19044694, compound

HRID 1682506Notes

Reaction equation

HRID 1682506 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[C:15]2[N:14]([CH3:16])[C:13]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[N:24]=[CH:25][NH:26][C:27]=4[CH3:28])[C:20](=[O:21])[C:12]=3[C:11]=2[CH:10]=[CH:9][CH:8]=1>O>[OH2:3].[OH2:21].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[F:6][C:7]1[C:15]2[N:14]([CH3:16])[C:13]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[N:24]=[CH:25][NH:26][C:27]=4[CH3:28])[C:20](=[O:21])[C:12]=3[C:11]=2[CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 3037237Lurosetron mesylate

Product 1

HCID 19044694HCID 19044694, compoundYield 113.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
45 °C

Procedure

To 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one methanesulphonate (33.0 g) was added water (112 ml) and the mixture heated to 45° C. to give a clear yellow solution. This solution was allowed to reach ambient temperature, then cooled to 10° C., whereupon the mixture was filtered and the solid washed with water (20 ml, at 10° C.). The solid was dried at 48° C. in vacuo for 16 hours to give the title compound (20.3 g).

Workup

  1. customto give a clear yellow solution
  2. customto reach ambient temperature
  3. temperaturecooled to 10° C., whereupon the mixture
  4. filtrationwas filtered
  5. washthe solid washed with water (20 ml, at 10° C.)
  6. customThe solid was dried at 48° C. in vacuo for 16 hours

Sources & evidence

ORD record
ord-e729269c83264ff4afb46bf3ce1fade3
Source dataset
uspto-grants-1997_06
Patent number
US05635513

Reaction notes

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