HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenylphenol → Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenylphenol | HCID 11381 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-(2,4-dichloro-6-methylpyrimidin-5-yl)acetate | HCID 19044674 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate | HCID 19044661 | — |
Reaction Steps
Methyl α-[6-methyl-2,4-dichloro-5-pyrimidinyl]-acetate (4 g, 18 mmol), 3-hydroxybiphenyl (3 g, 18 mmol) and potassium carbonate (11 g, 80 mmol) in dimethylformamide (50 ml) are stirred at +80° C. for 2 hours. Workup as for example 1a) gives pure methyl α-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate. 1H (CDCl3):7.65-7.05 (m, 9H); 3.82 (s, 2H); 3.76 (s, 3H); 2.52 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635508 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-3461324ac4cf49b5944914c91603e1e6 |
| Source note | uspto-grants-1997_06 |