Methanol → HCID 178499517, compound

HRID 1682535Notes

Reaction equation

HRID 1682535 reaction equation
[OH:1][C:2]1[C:7]([CH2:8][C:9]([OH:11])=[O:10])=[C:6]([CH3:12])[N:5]=[C:4]([SH:13])[N:3]=1.S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:10][C:9](=[O:11])[CH2:8][C:7]1[C:2]([OH:1])=[N:3][C:4]([SH:13])=[N:5][C:6]=1[CH3:12]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 178433551HCID 178433551, compound

Product 1

HCID 178499517HCID 178499517, compoundYield 79%

Procedure

A solution of (4-hydroxy-2-mercapto-6-methyl-5-pyrimidinyl)-acetic acid (190 g, 0.95 mol) and concentrated sulfuric acid (50 ml) in methanol (1.51) is refluxed for 18 hours. The suspension is cooled and filtered to give methyl(4-hydroxy-2-mercapto-6-methyl-5-pyrimidinyl)-acetate (160 g, 79%). 1H-NMR (DMSO):12.4 (s, 1H); 12.2 (s, 1H); 3.6 (s, 3H); 3.4 (s, 2H), 2.1 (s, 3H).

Workup

  1. temperatureThe suspension is cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-b26dca2f1a0e4d4f992064fc42c5b909
Source dataset
uspto-grants-1997_06
Patent number
US05635508

Reaction notes

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