Acetone → HCID 67723674, compound

Participants

Reaction Steps

The above ester (3.5 g, 13 mmol) was dissolved in ethanol (35 ml) and 4N sodium hydroxide (3.2 ml) was added. The mixture was stirred at ambient temperature overnight. The reaction mixture was diluted with water and 4M hydrochloric acid (6.3 ml) was added. The mixture was concentrated in vacuo and dichloromethane (50 ml) and acetone were added to the residue. The mixture was concentrated in vacuo to give a solid residue which was heated at reflux with acetone (500 ml). The mixture was filtered while still hot and the filtrate was left overnight for crystallisation. The solid which formed was isolated by filtration and dried to give 1.0 g of the title compound as a solid.

Provenance & Evidence