Hydrochloric Acid → HCID 67723784, compound

Participants

Reaction Steps

The above ester (1.4 g, 4 mmol) was dissolved in ethanol (30 ml) and 4N sodium hydroxide (4.5 ml) was added. The mixture was stirred at ambient temperature overnight. The reaction mixture was concentrated in vacuo to give a residue to which dichloromethane (175 ml) was added. The mixture was placed on an icebath and concentrated hydrochloric acid (2.1 ml) was added. The phases were separated and the organic phase was dried (Na2SO4). The solvent was evaporated in vacuo to give a residue which was dissolved in a mixture of dichloromethane (175 ml) and a small portion of water. The phases were separated and the organic phase was dried (Na2SO4). The solvent was evaporated in vacuo to give 0.4 g of the title compound as an oil.

Provenance & Evidence