Hydrochloric Acid → HCID 67723202, compound

Participants

Reaction Steps

The above ester (2.0 g, 5.7 mmol) was dissolved in ethanol (25 ml) and 4N sodium hydroxide (6.4 ml) was added. The mixture was stirred at ambient temperature for 3 h. Excess concentrated hydrochloric acid was added followed by a small portion of water. The mixture was concentrated in vacuo and dichloromethane (100 ml) and water (25 ml) were added. The phases were separated and the organic phase was dried (Na2S4). The solvent was evaporated in vacuo to give a solid residue which was recrystallised from acetone to give 1.2 g of title compound as a solid.

Provenance & Evidence