N4-Acetylsulfanilamide → trans-6-(4-Acetylaminobenzenesulfonamido)-1,3-dioxepane-5-ol

Participants

Reaction Steps

A mixture of 5,6-epoxy-1,3-dioxepane (0.5 g) and of 4-acetylaminobenzenesulfonamide (0.92 g) was heated in a sealed ampule at the temperature of 150° C. for 15 minutes. The mixture was cooled to room temperature, chromatographed on a silica gel column by elution with a mixture of ethyl acetate-methanol (9.5:0.5) and trans-6-(4-acetylaminobenzenesulfonamido)-1,3-dioxepane-5-ol was obtained. M.p. 208°-210° C./ethyl acetate-methanol (6:1).

Provenance & Evidence