反应详情

温度

100 °C

5-Chloro-N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]pyrazine-2-carboxamide (585 mg, 1.50 mmol) was added in one portion to 1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazine (379 mg, 3.00 mmol) in anhydrous dimethylsulfoxide (1.50 ml) at 25° C. The resulting solution was stirred at 100° C. for 18 h. The residue was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH to afford impure material. The concentrated eluent was purified by preparative HPLC, using decreasingly polar mixtures of water (containing 1% NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford impure product as a yellow solid. The impure material was then repurified by silica column chromatography, eluting with a gradient of 0 to 5% 7M NH3/MeOH in DCM. Pure fractions were evaporated to dryness to afford the title compound (269 mg, 37%) as a yellow solid.

1. customThe residue was purified by ion exchange chromatography
2. washThe desired product was eluted from the column
3. customto afford impure material
4. customThe concentrated eluent was purified by preparative HPLC
5. additionFractions containing the desired compound
6. customwere evaporated to dryness
7. customto afford impure product as a yellow solid
8. customThe impure material was then repurified by silica column chromatography
9. washeluting with a gradient of 0 to 5% 7M NH3/MeOH in DCM
10. customPure fractions were evaporated to dryness