HRID1682660

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID140381248

未命名化合物

HCID178451370

未命名化合物

PRODUCTS

产物

HCID178451373

未命名化合物

收率 84.4%

PROCEDURE

实验过程

In the same manner as in Example 15 (3), 5-(benzyloxycarbonyl-amidino)-2-benzofurancarboxylic acid (183 mg, 0.541 mmol) and t-butyl trans-(4-aminocyclohexyloxy)acetate (124 mg, 0.541 mmol) were condensed, and purified by silica gel column chromatography (methylene chloride/methanol=30/1-10/1) to give 251 mg of compound (170) as a colorless solid (84%).

WORKUP

后处理

customcondensed
custompurified by silica gel column chromatography (methylene chloride/methanol=30/1-10/1)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-35843e99358447f69bb921037c28ae9c
来源数据集: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05635527
来源说明: uspto-grants-1997_06

反应SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([C:22]([OH:24])=O)=[CH:19][C:18]=2[CH:25]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:26][C@H:27]1[CH2:32][CH2:31][C@H:30]([O:33][CH2:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:29][CH2:28]1>>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]2[O:21][C:20]([C:22]([NH:26][C@H:27]3[CH2:32][CH2:31][C@H:30]([O:33][CH2:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:29][CH2:28]3)=[O:24])=[CH:19][C:18]=2[CH:25]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1