Hydrochloric Acid → HCID 178479325, compound

Participants

Reaction Steps

Tetrahydrofuran (5 ml) was added to ethyl 5-benzylamidino-2-benzofurancarboxylate (325 mg, 1.21mmol) and a 0.5N aqueous sodium hydroxide solution (10 ml, 5 mmol) was added. The mixture was stirred at room temperature for 45 minutes. 1N Hydrochloric acid was added to the reaction mixture to adjust its pH to 2-3 and low boiling matters were distilled away under reduced pressure. The resulting precipitate was collected by filtration, and washed with water to give 213 mg of 5-benzylamidino-2-benzofurancarboxylic acid hydrochloride as a colorless solid (53%).

Provenance & Evidence