HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride → ethyl (S)-2-[(N-benzyloxycarbonyl-4-piperidinyloxy)acetylamino]-3-(4-nitrophenyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride | HCID 6453710 | — |
| Reactant | 2-((1-((Benzyloxy)carbonyl)piperidin-4-YL)oxy)acetic acid | HCID 18919494 | — |
| Product | ethyl (S)-2-[(N-benzyloxycarbonyl-4-piperidinyloxy)acetylamino]-3-(4-nitrophenyl)propionate | HCID 86750902 | 76.1% |
Reaction Steps
In the same manner as in Example 67 (1), [N-benzyloxycarbonyl-4-piperidinyloxy]acetic acid (530 mg, 1.81 mmol) and ethyl (S)-2-amino-3-(4-nitrophenyl)propionate hydrochloride (500 mg, 1.82 mmol) were condensed to give 707 mg of ethyl (S)-2-[(N-benzyloxycarbonyl-4-piperidinyloxy)acetylamino]-3-(4-nitrophenyl)propionate as a yellow oil (76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635527 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-79391802f8694f27ad034bf1e60ed4f2 |
| Source note | uspto-grants-1997_06 |