HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(4-chlorophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 2-Amino-1-(4-chlorophenyl)ethan-1-ol | HCID 412434 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Methyl 4-(2-oxopropoxy)phenylacetate | HCID 21832178 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(4-chlorophenyl)ethanol | HCID 53655583 | 35% |
Reaction Steps
Following a procedure similar to that described in Example 12, but using 2 g of 2-amino-1-(4-chlorophenyl)ethanol (prepared as described in Preparation 12), 3.11 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 50 ml of absolute methanol and 2.7 g of sodium cyanoborohydride, 1.54 g of the title compound were obtained as crystals, melting at 78°-79° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635534 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-b30cc454e261435ca9604626d1d5f746 |
| Source note | uspto-grants-1997_06 |