Tyrosol → 2-[4-(2-Oxopropoxy)phenyl]ethanol

HRID 1682738ノート

反応式

HRID 1682738 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1.Br[CH2:12][C:13](=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:15]=[C:13]([CH3:14])[CH2:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 10393TyrosolHCID 11430Potassium CarbonateHCID 11715Bromoacetone

生成物 1

HCID 218321652-[4-(2-Oxopropoxy)phenyl]ethanol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Following a procedure similar to that described in Preparation 3, but using 10 g of 2-(4-hydroxyphenyl)ethanol, 21.6 g of bromoacetone, 30 g of potassium carbonate and 100 ml of dimethylformamide, the title compound was obtained having an Rf=0.31 (thin layer chromatography over silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

後処理

  1. customthat described in Preparation 3

出典と根拠

ORDレコード
ord-3c91169978f94362a5ed8894f3ff973a
出典データセット
uspto-grants-1997_06
特許番号
US05635534

反応ノート

読み込み中…