Dichloromethane → HCID 67562171, compound

HRID 1682974Notes

Reaction equation

HRID 1682974 reaction equation
[C:1]1([C:7]2([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][C:31]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)([C:34]([NH2:36])=[O:35])[CH2:30][CH2:29]3)[CH2:11][CH2:10][N:9]([C:12](=[O:25])[C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[C:15]([O:23][CH3:24])[CH:14]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:43]CCl>>[ClH:43].[C:1]1([C:7]2([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][C:31]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)([C:34]([NH2:36])=[O:35])[CH2:30][CH2:29]3)[CH2:11][CH2:10][N:9]([C:12](=[O:25])[C:13]3[CH:14]=[C:15]([O:23][CH3:24])[C:16]([O:21][CH3:22])=[C:17]([O:19][CH3:20])[CH:18]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 54374150HCID 54374150, compound

Product 1

HCID 67562171HCID 67562171, compound

Procedure

Prepared by the method of example 3.3A using 1-[2-[3-phenyl-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide (710 mg, 1.24 mmol) and dichloromethane saturated with HCl(gas) (20 mL). The solution was concentrated in vacuo to obtain a residue. The residue was dried under high vacuum at 56° C. for 18 h to afford the title compound:

Workup

  1. customPrepared by the method of example 3.3A
  2. concentrationThe solution was concentrated in vacuo
  3. customto obtain a residue
  4. customThe residue was dried under high vacuum at 56° C. for 18 h

Sources & evidence

ORD record
ord-186359afd3ba497aa318899d6ebdb2f9
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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