HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethoxybenzoyl chloride → [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)-1-pyrrolidinyl](3,5-dimethoxyphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethoxybenzoyl chloride | HCID 87003 | — |
| Reactant | 2-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol | HCID 18464427 | — |
| Product | [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)-1-pyrrolidinyl](3,5-dimethoxyphenyl)methanone | HCID 54501447 | — |
Reaction Steps
The method of example 3.1 was used with 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (1 mmol) and 3,5-dimethoxy-benzoyl chloride (1 mmol) to prepare the title compound. Chromatography on silica gel eluting sequentially with ethyl acetate and then 6% methanol in dichloromethane gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635510 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-78aa84ec03754ff99ac79bff446d99e9 |
| Source note | uspto-grants-1997_06 |