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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1682981Generated: November 3, 2026

3,5-Dimethoxybenzoyl chloride → [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)-1-pyrrolidinyl](3,5-dimethoxyphenyl)methanone

https://huagongshe.com/reaction/1682981

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Dimethoxybenzoyl chlorideHCID 87003—
Reactant2-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanolHCID 18464427—
Product[3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)-1-pyrrolidinyl](3,5-dimethoxyphenyl)methanoneHCID 54501447—

Reaction Steps

The method of example 3.1 was used with 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (1 mmol) and 3,5-dimethoxy-benzoyl chloride (1 mmol) to prepare the title compound. Chromatography on silica gel eluting sequentially with ethyl acetate and then 6% methanol in dichloromethane gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05635510
Source datasetuspto-grants-1997_06
ORD IDord-78aa84ec03754ff99ac79bff446d99e9
Source noteuspto-grants-1997_06