4-Phenylpiperidine-4-carboxamide monohydrochloride → 2-[3-(3,4-Dichloro-phenyl)-1-(3,5-dimethoxy-benzoyl)-pyrrolidin-3-yl-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

Participants

Reaction Steps

The method of example 3.3 was used with 2-[3-(3,4-dichloro-phenyl)-1-(3,5-dimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (0.96 mmol) and 4-phenylpiperidine-4-carboxylic acid amide hydrochloride (1.06 mmol) to prepare the title compound. Chromatography on silica gel eluting sequentially with ethyl acetate, 6% methanol in dichloromethane, and then 10% methanol in dichloromethane gave the title compound:

Provenance & Evidence