Dimethylamine → N,N-dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide

HRID 1683021Notes

Reaction equation

HRID 1683021 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:14](O)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:23]([CH3:25])[CH3:24]>>[CH3:24][N:23]([CH3:25])[C:14]([C:11]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]1)=[O:15]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 7369171-((Tert-butoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid

Product 1

HCID 22741799N,N-dimethyl-1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxamide

Procedure

Prepare by the method of example 20.8 using 1-tert-butoxycarbonyl-4-phenyl-piperidine-4-carboxylic acid (4.0 mmol) and (CH3)2NH. Purify to give the title compound.

Workup

  1. customPurify

Sources & evidence

ORD record
ord-297c7fe09d8e4f5eb91fc49e286f1387
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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