2-Chloro-1-(3,4,5-trimethoxyphenyl)ethan-1-one → HCID 54072957, compound

HRID 1683036Notes

Reaction equation

HRID 1683036 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30])[C:22](=[O:25])[CH2:23]Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([CH2:23][C:22]([C:21]3[CH:26]=[C:27]([O:31][CH3:32])[C:28]([O:29][CH3:30])=[C:19]([O:18][CH3:17])[CH:20]=3)=[O:25])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 127899762-Chloro-1-(3,4,5-trimethoxyphenyl)ethan-1-oneHCID 184644272-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol

Product 1

HCID 54072957HCID 54072957, compound

Procedure

Prepare by the method of example 3.1 using 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (2 mmol) and 3,4,5-trimethoxy-phenacyl chloride (2 mmol). Chromatograph on silica gel to give the title compound. Rf =0.45 (6% methanol/dichloromethane).

Sources & evidence

ORD record
ord-e705a6dd4e844dd4b7e5c824ed52727b
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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