Benzoyl chloride, 3,4,5-trimethoxy- → HCID 18333578, compound

HRID 1683055Notes

Reaction equation

HRID 1683055 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:27]=[C:28]([O:32][CH3:33])[C:29]=1[O:30][CH3:31])[C:24](Cl)=[O:25]>>[F:18][C:2]([F:17])([F:1])[C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][CH2:15][OH:16])[CH2:13][CH2:12][N:11]([C:24](=[O:25])[C:23]3[CH:22]=[C:21]([O:20][CH3:19])[C:29]([O:30][CH3:31])=[C:28]([O:32][CH3:33])[CH:27]=3)[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 18333344HCID 18333344, compound

Product 1

HCID 18333578HCID 18333578, compound

Procedure

Prepare by the method of example 3.1 using 2-[3-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-ethanol (23 mmol) and 3,4,5-trimethoxy-benzoyl chloride (23 mmol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record
ord-72de6f0dce984af08013fc2aedc8e881
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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