Ethyl bromoacetate → 3-cyano-3-(pyrid-3-yl)pentanedioic Acid Diethyl Ester

HRID 1683061Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1.Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH2:11][C:7]([C:8]#[N:9])([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:16]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 809233-Pyridineacetonitrile

Product 1

HCID 541828903-cyano-3-(pyrid-3-yl)pentanedioic Acid Diethyl Ester

Procedure

Prepare by the method of example 1.1.2 using pyridin-3-yl-acetonitrile (0.161 mol) and ethyl bromoacetate (0.325 mol). Chromatograph on silica gel to give the title compound.

Sources & evidence

ORD record: ord-2535fdb23cfc4c14a4191e07e3c96fe8
Source dataset: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05635510

Reaction notes

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