HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-(Tert-butyldimethylsilyloxy)-phenyl-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Hydroxybenzyl cyanide | HCID 26548 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(Tert-butyldimethylsilyloxy)-phenyl-acetonitrile | HCID 18333582 | — |
Reaction Steps
Combine tert-butyldimethylsilyl chloride (0.460 mol), imidazole (0.600 mol) and DMF (125 mL). Add 4-hydroxyphenylacetonitrile (0.400 mol) and maintain at ambient temperature for 16 h. Dilute with ether (500 mL), extract with water (4×75 mL), saturated sodium chloride (75 mL), dry over MgSO4, filter, and concentrate in vacuo to obtain a residue. Chromatograph on silica gel to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635510 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-8493f9f6d3d2492c95b33db810e82e79 |
| Source note | uspto-grants-1997_06 |