HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1683082Generated: November 2, 2026
Benzoyl chloride, 3,4,5-trimethoxy- → 4-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one
https://huagongshe.com/reaction/1683082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl chloride, 3,4,5-trimethoxy- | HCID 78282 | — |
| Reactant | 4-(2-Tetrahydropyranyloxyethyl)-4-(3,4-dichlorophenyl)-2-pyrrolidone | HCID 21197671 | — |
| Solvent | N,N-Dimethylaniline | HCID 949 | — |
| Product | 4-(3,4-Dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-2-one | HCID 53799801 | — |
Reaction Steps
Combine 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)ethyl]-pyrrolidin-2-one (as prepared in example 11.3) (5 mmol) and 3,4,5-trimethoxy-benzoyl chloride (5.0 mmol) in N,N-dimethylaniline (20 mL). Heat to 90° C. and stir for 24 h. Concentrate in vacuo . Partition the reaction mixture between dichloromethane and H2O. Separate the organic layer, dry over MgSO4, filter, and concentrate in vacuo to obtain a residue. Purify to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05635510 |
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| Source dataset | uspto-grants-1997_06 |
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| ORD ID | ord-146fde8b8e4c4bdeb6434dcb32d2c965 |
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| Source note | uspto-grants-1997_06 |
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