HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 53938007, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(Bromomethyl)-1,2,3-trimethoxybenzene | HCID 10355271 | — |
| Reactant | 3-Tetrahydropyranyloxyethyl-3-(3,4-dichlorophenyl)pyrrolidine | HCID 21197687 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 53938007 | HCID 53938007 | — |
Reaction Steps
Combine 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy) -ethyl]-pyrrolidine (10 mmol), K2CO3 (30 mmol), and 3,4,5-trimethoxy-benzyl bromide (10 mmol) in THF/H2O (4/1, 200 mL). Heat to reflux and stir for 16 h. Concentrate in vacuo to obtain a residue. Dilute the residue with ethyl acetate and extract with H2O. Separate the layers, dry the organic layer over MgSO4, filter, and concentrate in vacuo. Chromatograph on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635510 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-d3dc4509ce084b41be2ca025b53f618a |
| Source note | uspto-grants-1997_06 |