HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 4-(3,4-Dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trimethoxy-benzyl)-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | HCID 53938007 | HCID 53938007 | — |
| Product | 4-(3,4-Dichloro-phenyl)-4-2-hydroxy-ethyl-1-(3,4,5-trimethoxy-benzyl)-pyrrolidine | HCID 54409184 | — |
Reaction Steps
Prepare according to the method of example (11.5) using 4-(3,4-dichloro-phenyl)-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(3,4,5-trimethoxy-benzyl)-pyrrolidine (3 mmol) and p-toluenesulfonic acid (200 mg). Chromatograph on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05635510 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-d0366ecaa8f142f2b2a303a5b7e02c25 |
| Source note | uspto-grants-1997_06 |