反应详情

To a rapidly stirred mixture of 2-methoxy-5-chlorosulfonylbenzoic acid (5.0 g, 20 mmol) and phenol (1.88 g, 20 mmol) in water (100 mL) was added dropwise a solution of sodium hydroxide (16 mL, 10%; 40 mmol) over 10 min. The mixture was stirred for 18 h, and then extracted with ether. The aqueous phase was acidified to pH 1 with cone. HCl and the white precipitate filtered off to give the title compound (4.05 g).

1. extractionextracted with ether
2. filtrationHCl and the white precipitate filtered off