HCID 19042872, compound → HCID 19042874, compound

HRID 1683286Notes

Reaction equation

HRID 1683286 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([C:16]([O:18]CC)=[O:17])=[CH:10]2>[OH-].[Na+]>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([C:16]([OH:18])=[O:17])=[CH:10]2

Participants

3

Reactant 1

HCID 19042872HCID 19042872, compound

Product 1

HCID 19042874HCID 19042874, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 5-(3-trifluoromethylphenoxy)indole-2-carboxylate (0.8 g, 2.29 mmol) was hydrolysed in methanolic NaOH (3.2M, 4.0 mL) at reflux, for 1 hr. After work-up the product: 5-(3-trifluoromethylphenoxy)indole-2-carboxylic acid was obtained as an almost white solid, 0.73 g (ca 100%).

Workup

  1. temperatureat reflux, for 1 hr

Sources & evidence

ORD record
ord-27a01ee89a4d43758779ea476ebbd9fc
Source dataset
uspto-grants-1997_06
Patent number
US05637593

Reaction notes

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