HCID 19042847, compound → HCID 19042857, compound

HRID 1683289Notes

Reaction equation

HRID 1683289 reaction equation
[Cl:1][C:2]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:18]([O:20]CC)=[O:19])[NH:6]2>[OH-].[Na+]>[Cl:1][C:2]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:18]([OH:20])=[O:19])[NH:6]2

Participants

3

Reactant 1

HCID 19042847HCID 19042847, compound

Product 1

HCID 19042857HCID 19042857, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 4-chloro-5-phenoxyindole-2-carboxylate (0.302 g, 0.956 mmol) was hydrolysed in methanolic NaOH (3.2M, 1.7 mL) at reflux, for 1.5 hr After work-up, the product: 4-chloro-5-phenoxyindole-2-carboxylic acid was obtained as an almost white solid, 0.275 g (ca 100%).

Workup

  1. temperatureat reflux, for 1.5 hr After work-up

Sources & evidence

ORD record
ord-7bf2f2e4e34143af8bbb3ce9f730e4a0
Source dataset
uspto-grants-1997_06
Patent number
US05637593

Reaction notes

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