1-Methyl-4-piperidone → HCID 19042870, compound

Participants

Reaction Steps

5-Phenylthioindole (0.50 g, 2.22 mmol), 1-methylpiperid-4-one (0.292 g, 0.32 mL, 2.58 mmol) and sodium methoxide (0.139 g) were heated at reflux in MeOH (25 mL) for 20 hr. After cooling and work-up, 3-(1-methyl-1,2,5,6-tetrahydropyrid-4-yl)-5-phenylthioindole was obtained as a pale yellow solid, 0.399 g, (56%). This free base (0.20 g) was treated with fumaric acid (0.11 g, 0.94 mmol) in MeOH/Et2O to give: 3-(1-methyl-1,2,5,6-tetrahydropyrid-4-yl)-5-phenylthioindole fumarate, 0.124 g (46%), m.p. 225°-28° C.

Provenance & Evidence