Water → HCID 19043489, compound

Participants

Reaction Steps

Propionyl chloride (9.25 g, 0.1 mol) was added dropwise to a solution of 1-(2-methylpropyl)-4,4-dimethyl-1,4,5,6-tetrahydropyridine (16.7 g, 0.1 mol) and triethylamine (12.1 g, 0.12 mol) in dichloromethane (100 ml) stirring under an atmosphere of nitrogen at ice bath temperature. After one hour at this temperature, water (50 ml) was added, the organic layer was separated, washed with 5% aqueous sodium carbonate and dried over anhydrous MgSO4. Removal of the organic solvent afforded a yellow oil (22.3 g, quantitative) which was essentially pure by 90 MHz NMR spectroscopy. After column chromatography on silica-gel (Merck Kieselgel 60, 70-230 mesh) using 5% diethyl ether in dichloromethane (or 3:7 ether: n-hexane) as eluent, the pure 1-(2-methylpropyl)-3-propionyl-4,4-dimethyl-1,4,5,6-tetrahydropyridine (18.0 g, 81%) was obtained as a very pale yellow oil. UV λ max MeOH 307 nm, 29,300. 1H NMR (CDCl3) δ7.13 (1H, s), 3.10 (2H, m, AAIXXI system), 2.94 (2H, d, J7.4Hz), 2.44 (2H, q, J7.5Hz), 1.95 (1H, m, J6.6Hz, J7.4Hz), 1.60 (2H, m, AAIXXI system), 1.27 (6H, s), 1.08 (3H, t, J7.5 Jz), and 0.90 (6H, d, J6.6Hz). 13C NMR (CDCl3) δ195.9 (s), 147.9 (d), 114,4 (s), 64.1 (t), 43.3 (t), 39.3 (t), 30.0 (s), 29.7 (t), 28.1 (q), 27.4 (d), 19.8 (q), and 10.3 (q). MS 223.1913 (M+), 25.2%, 194 (100%).

Provenance & Evidence