Sodium sulfate decahydrate → HCID 19043493, compound

Participants

Reaction Steps

A solution of N-(2-Methylpropyl)-3,3-dimethylglutarimide (19.5 g, 0.0984 mol) in dry ether (30 ml) was added via a dropping funnel over 30 minutes to a suspension of lithium aluminum hydride (5.36 g, 0.141 mol) in dry ether (50 ml) at 0° C. stirring under nitrogen. The mixture was then boiled for 3 hours, allowed to cool to room temperature and the excess lithium aluminium hydride was decomposed by careful addition of solid sodium sulphate decahydrate (20 g). After the suspended solid had turned white, the mixture was filtered, the solid washed twice with ether (2×50 ml), and the combined filtrate concentrated to yield a colourless liquid. Distillation gave the pure product, (1-(2-methylpropyl)-4,4-dimethylpipeidine, 13.0 g (82%), b.p. 81°-82° C./16 mmHg. 1H NMR (CDCl 3) δ2.30 (4H, t), 2.05 (2H, d), 1.80 (1H, m), 1.35 (4H, t), 0.90 (6H, s) and 0.85 (6H, d).

Provenance & Evidence