Dimethylamine → HCID 19043729, compound

HRID 1683439Notes

Reaction equation

HRID 1683439 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=3)=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[CH3:25][NH:26][CH3:27]>C(O)C>[ClH:23].[CH3:25][N:26]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=3)=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)[CH3:27]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19043698HCID 19043698, compound

Product 1

HCID 19043729HCID 19043729, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 g of 3,4-dichlorophenyl 4'-bromomethyl-4-biphenylyl ketone and 20 ml of a 33 percent solution of dimethylamine in ethanol are heated to boiling for 4 hours, whereupon the mixture is evaporated. The residue is taken up in ether and treated with an ethereal hydrogen chloride solution. The precipitated hydrochloride is filtered and dried. 3,4-Dichlorophenyl 4'-[(dimethylamino)methyl]-4-biphenylyl ketone hydrochloride, m.p. 223° C., is obtained.

Workup

  1. customis evaporated
  2. additiontreated with an ethereal hydrogen chloride solution
  3. filtrationThe precipitated hydrochloride is filtered
  4. customdried

Sources & evidence

ORD record
ord-e8fe5e7ad746481cb9740e9d11b627d0
Source dataset
uspto-grants-1997_06
Patent number
US05637771

Reaction notes

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