HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate → (2S)-[2-[(t-Butoxycarbonyl)amino]-1-hydroxy-4-methylpentyl]bis(4-chlorophenyl)phosphine oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate | HCID 104275 | — |
| Reactant | 1-chloro-4-(4-chlorophenyl)phosphonoylbenzene | HCID 178527030 | — |
| Product | (2S)-[2-[(t-Butoxycarbonyl)amino]-1-hydroxy-4-methylpentyl]bis(4-chlorophenyl)phosphine oxide | HCID 22873484 | 83% |
Reaction Steps
t-Boc-Leu-H; bis(4-chlorophenyl)phosphine oxide; 2.5 hours; yield 83% (2S)-[2-[(t-Butoxycarbonyl)amino]-1-hydroxy-4-methylpentyl]bis(4-chlorophenyl)phosphine oxide; MS: 486, 488 m/z (M+H)+, dichloro isotope pattern.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639732 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-6868fdf58da1413eba4695a664ca8798 |
| Source note | uspto-grants-1997_06 |