HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Amino-2-cyano-6-[(4-chlorophenyl)ethynyl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Chloro-4-iodobenzene | HCID 12510 | — |
| Reactant | 3-Amino-6-ethynylpicolinonitrile | HCID 19040788 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Amino-2-cyano-6-[(4-chlorophenyl)ethynyl]pyridine | HCID 19040786 | — |
Reaction Steps
This compound is prepared in a manner analogous to that of Step C of Example 9, using 3.1 grams (0.022 mole) of 3-amino-2-cyano-6-ethynylpyridine, 7.4 grams (0.031 mole) of 4-chlorophenyl iodide, 10.7 grams (0.077 mole) of triethylamine, 0.5 gram (catalyst) of bis(triphenylphosphine)palladium(II) chloride, and 0.5 gram (catalyst) of copper iodide in 100 mL of acetonitrile, yielding 3-amino-2-cyano-6-[(4-chlorophenyl)ethynyl]pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639753 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-38d324c81545465e81b47fb5b352a8da |
| Source note | uspto-grants-1997_06 |