化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 2-Amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Amino-6-bromopyrazine-2-carbonitrile | HCID 11052611 | — |
| 反応物 | 2,3-Dihydro-3-hydroxy2,2-dimethylbenzofuran-7-ylboronic acid | HCID 19040776 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine | HCID 19040783 | — |
反応手順
This compound is prepared in a manner analogous to that of Step A of Example 4, using 1.6 grams (0.008 mole) of 2-amino-3-cyano-5-bromopyrazine, 2.5 grams (0.012 mole) of 2,3-dihydro-3-hydroxy-2,2-dimethyl-benzofuran-7-ylboronic acid, 4.3 grams (0.031 mole) of potassium carbonate and 0.3 gram of tetrakis(triphenylphosphine)palladium(0) in 150 mL of toluene, yielding 2-amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05639753 |
| 出典データセット | uspto-grants-1997_06 |
| ORD ID | ord-143cb4e577f24336b2b420b810f7ea43 |
| 出典メモ | uspto-grants-1997_06 |