HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Phenacyl-2-(2-chloroethylamino)benzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-{2-[(2-hydroxyethyl)amino]-1H-benzimidazol-1-yl}-1-phenylethanone | HCID 2850100 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-Phenacyl-2-(2-chloroethylamino)benzimidazole hydrochloride | HCID 19040830 | 90% |
Reaction Steps
Add 0.7 ml (10 mmol) of freshly distilled thionyl chloride, with stirring, to a suspension of 1.5 g (5 mmol) of the base obtained above in 25 ml of anhydrous chloroform. Heat the resulting solution at reflux for 1 hour. After cooling, the 1 -phenacyl-2-(2-chloroethylamino)benzimidazole hydrochloride precipitate is isolated by filtration, washed with petroleum ether and recrystallised from a mixture of ethanol/ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639756 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-8e5cfff38baf4276962e06bf2fed4d5b |
| Source note | uspto-grants-1997_06 |