HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amine → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amine | HCID 566559 | — |
| Reactant | 2-Bromo-1-(5-bromothiophen-2-yl)ethan-1-one | HCID 1988398 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide | HCID 19040891 | 82% |
Reaction Steps
Add a solution of 5-bromo-2-bromoacetylthiophene (5.68 g, 20 mmol) in 30 ml of ether to a hot solution of 2-amino-1-(2-piperidinoethyl)-benzimidazole (4.88 g, 20 mmol) in 150 ml of acetone. Stir and maintain at room temperature for five hours. Suction-filter the precipitate, wash with acetone and then with ether to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639756 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-09dc6e31311848d7b8eee112da9f40b2 |
| Source note | uspto-grants-1997_06 |