HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenacyl bromide → 2-(3-Hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | 3-(1H-Benzimidazol-2-ylamino)-1-propanol | HCID 2003325 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(3-Hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide | HCID 19040862 | — |
Reaction Steps
Heat at reflux for 5 to 6 hours a mixture of 1.91 g (10 mmol) of the compound obtained in Step A and 1.99 g (10 mmol) of phenacyl bromide in 20 ml of isopropanol. Cool. Collect the title compound precipitate by filtration and wash with acetone. Recrystallise from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639756 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-02088260d68f4bad9c14e090ca107390 |
| Source note | uspto-grants-1997_06 |