Hydrochloric Acid → HCID 88380185, compound

Participants

Reaction Steps

The above ester (0.6 g, 1.6 mmol) was dissolved in ethanol (5 ml) and 4N sodium hydroxide (1.6 ml) was added. The mixture was stirred at ambient temperature for 20 h, placed on an ice-bath and excess concentrated hydrochloric acid was added. The mixture was concentrated in vacuo and dichloromethane (300 ml) was added. The phases were separated and the organic phase was washed with water (5 ml) and dried (MgSO4). The solvent was evaporated in vacuo to give 0.52 g of the title compound as an amorphous solid.

Provenance & Evidence