反应详情

A mixture of 2-phenyl-2-cyclohexen-1-one (0.6 g, 3.5 mmol, Tetrahedron 1972, 28, 2369), hydroxylammonium chloride (0.5 g, 7 mmol) and dry pyridine (15 ml) was heated at reflux for 3 h. The reaction mixture was allowed to cool and the solvent was evaporated in vacuo. The residue was dissolved in a mixture of ethyl acetate and water. A 10% citric acid solution was added until acidic pH and the phases were separated. The organic phase was extracted with a 10% citric acid solution and dried (MgSO4). The solvent was evaporated in vacuo to give 0.55 g of 2-phenyl-2-cyclohexen-1 -one oxime. M.p. 144°-146° C.

1. temperaturewas heated
2. temperatureat reflux for 3 h
3. temperatureto cool
4. customthe solvent was evaporated in vacuo
5. dissolutionThe residue was dissolved in a mixture of ethyl acetate and water
6. additionA 10% citric acid solution was added until acidic pH
7. customthe phases were separated
8. extractionThe organic phase was extracted with a 10% citric acid solution
9. dry with materialdried (MgSO4)
10. customThe solvent was evaporated in vacuo