反应详情

A mixture of 2-phenyl-1-tetralone (1.1 g, 5 mmol, J. Am. Chem. Soc. 1949, 71, 1092), hydroxylammonium chloride (0.7 g, 10 mmol) and dry pyridine (30 ml) was heated at reflux for 4 h and then stirred at ambient temperature overnight. The solvent was evaporated in vacuo and the residue was stirred in a mixture of ethyl acetate (50 ml) and 10% citric acid (50 ml). The phases were separated and the organic phase was washed with water and dried (MgSO4). The solvent was evaporated in vacuo to give 1.2 g of 2-phenyl-1-tetralone oxime as a solid. M.p. 156°-157° C.

1. temperaturewas heated
2. temperatureat reflux for 4 h
3. customThe solvent was evaporated in vacuo
4. stirringthe residue was stirred in a mixture of ethyl acetate (50 ml) and 10% citric acid (50 ml)
5. customThe phases were separated
6. washthe organic phase was washed with water
7. dry with materialdried (MgSO4)
8. customThe solvent was evaporated in vacuo