Hydrochloric Acid → (R)-1-(2-(((2-Phenyl-1,2,3,4-tetrahydro-1-naphthylidene)amino)oxy)ethyl)-3-piperidinecarboxylic acid hydrochloride

Participants

Reaction Steps

The above ester (0.6 g, 1.5 mmol) was dissolved in ethanol (10 ml) and 4N sodium hydroxide (1.1 ml) was added. The mixture was stirred at ambient temperature for 4 h and excess concentrated hydrochloric acid was added followed by dichloromethane (300 ml). The mixture was dried (MgSO4) and the solvent evaporated in vacuo to give a residue which was re-evaporated with acetone and recrystallised from acetone. This afforded 0.5 g of the title compound as a solid.

Provenance & Evidence