Thionyl Chloride → HCID 19040618, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 9-chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine-6-propanol (0.8 g, 3 mmol) in methylene chloride (30 ml) was stirred at 5° C. and treated with thionyl chloride (40 ml). The mixture was stirred for 10 minutes at 5° C., 15 minutes at 25° C., 3 hours at 55° C. and 16 hours at 25° C. The mixture was concentrated to give 0.96 g of 6-chloro-9-(3-chloropropyl)-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride.

Provenance & Evidence