3,4-Diethoxybenzene-1-carbothioamide → HCID 18707257, compound

HRID 1683780Notes

Reaction equation

HRID 1683780 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12](=O)[CH2:13]Br)[N:7]=1)=[O:5])C.[CH2:16]([O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH2:29][CH3:30])[C:22]([NH2:24])=[S:23])[CH3:17]>>[CH2:16]([O:18][C:19]1[CH:20]=[C:21]([C:22]2[S:23][CH:13]=[C:12]([C:8]3[N:7]=[C:6]([C:4]([OH:3])=[O:5])[CH:11]=[CH:10][N:9]=3)[N:24]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH2:29][CH3:30])[CH3:17]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 187071244-Ethoxycarbonyl-2-(alpha-bromoacetyl)pyrimidine

Product 1

HCID 18707257HCID 18707257, compound

Procedure

A reaction was conducted in the same manner as in Example 1, by using 4-ethoxycarbonyl-2-(α-bromoacetyl)pyrimidine and 3,4-diethoxythiobenzamide. Then, hydrolysis was conducted in the same manner as in Example 2 to obtain 2-(3,4-diethoxyphenyl)-4-(4-carboxy-2-pyrimidyl)thiazole.

Workup

  1. customThen, hydrolysis

Sources & evidence

ORD record
ord-de7818345784477bbf96cfa9aeb51660
Source dataset
uspto-grants-1997_06
Patent number
US05639770

Reaction notes

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