3,4-Diethoxybenzene-1-carbothioamide → HCID 19041056, compound

HRID 1683783Notes

Reaction equation

HRID 1683783 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([O:11]CC)=[O:10])[N:6]=[C:5]([C:14](=O)[CH2:15]Br)[CH:4]=1.[CH2:18]([O:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][CH3:32])[C:24]([NH2:26])=[S:25])[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:22]=[C:23]([C:24]2[S:25][CH:15]=[C:14]([C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]=3)[N:26]=2)[CH:27]=[CH:28][C:29]=1[O:30][CH2:31][CH3:32])[CH3:19]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 19041050HCID 19041050, compound

Product 1

HCID 19041056HCID 19041056, compound

Procedure

A reaction was conducted in the same manner as in Example 1, by using 4-methoxy-6-ethoxycarbonyl-2-(α-bromoacetyl)pyridine and 3,4-diethoxythiobenzamide. Then, hydrolysis was conducted in the same manner as in Example 2 to obtain 2-(3,4-diethoxyphenyl)-4-(4-methoxy-6-carboxy-2-pyridyl)thiazole.

Workup

  1. customThen, hydrolysis

Sources & evidence

ORD record
ord-3838c4973fec47a398458fb56cdf90f7
Source dataset
uspto-grants-1997_06
Patent number
US05639770

Reaction notes

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