3,4-Diethoxybenzene-1-carbothioamide → HCID 19041052, compound

HRID 1683785Notes

Reaction equation

HRID 1683785 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]CC)=[O:9])[N:5]=[C:4]([C:13](=O)[CH2:14]Br)[CH:3]=1.[CH2:17]([O:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=1[O:29][CH2:30][CH3:31])[C:23]([NH2:25])=[S:24])[CH3:18]>>[CH2:17]([O:19][C:20]1[CH:21]=[C:22]([C:23]2[S:24][CH:14]=[C:13]([C:4]3[CH:3]=[C:2]([NH2:1])[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5]=3)[N:25]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH2:30][CH3:31])[CH3:18]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 19041115HCID 19041115, compound

Product 1

HCID 19041052HCID 19041052, compound

Procedure

A reaction was conducted in the same manner as in Example 1, by using 4-amino-6-ethoxycarbonyl-2-(α-bromoacetyl)pyridine and 3,4-diethoxythiobenzamide. Then, hydrolysis was conducted in the same manner as in Example 2 to obtain 2-(3,4-diethoxyphenyl)-4-(4-amino-6-carboxy-2-pyridyl)thiazole.

Workup

  1. customThen, hydrolysis

Sources & evidence

ORD record
ord-92ee2b925ae04fbb933fbb7d566dc602
Source dataset
uspto-grants-1997_06
Patent number
US05639770

Reaction notes

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